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Synopsis
The purpose of the present investigation was to design and evaluate sustained release tablets of a sparingly water soluble drug Ambroxol Hydrochloride, two hydrophilic polymers METHOCEL K15MCR and METHOCEL K100MCR and hydrophobic Eudragit RL100 were used in tablets prepared by direct compression. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content. The tablets were subjected to various tests for physical parameters such as thickness, hardness and friability, and in vitro release studies. The in vitro dissolution study was carried out for 12 hours using United States Pharmacopoeia (USP) paddle-type dissolution apparatus (Apparatus 2) in phosphate buffer (pH 6.8). The results of dissolution studies indicated that formulations containing Methocel K100 MCR showed better dissolution properties compared to formulaitons containing Methocel K15 MCR.It was found that Hydrophilic polymers showed better released profile than the hydrophobic polymers.
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About the Author
Dewan Taslima Akhter has obtained her BPharm (Hons.) and MS degree from Jahangirnagar University. Naz H. Huda is graduated from Khulna University and obtained MS degree from United Kingdom. Tajnin Ahmed has obtained her M.Pharm degree from USTC. Authors are Pharmacists and currently working in Department of Pharmacy, Stamford University Bangladesh.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3847346067
- ISBN 13 9783847346067
- BindingPaperback
- LanguageEnglish
- Number of pages140
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The purpose of the present investigation was to design and evaluate sustained release tablets of a sparingly water soluble drug Ambroxol Hydrochloride, two hydrophilic polymers METHOCEL K15MCR and METHOCEL K100MCR and hydrophobic Eudragit RL100 were used in tablets prepared by direct compression. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity and drug content. The tablets were subjected to various tests for physical parameters such as thickness, hardness and friability, and in vitro release studies. The in vitro dissolution study was carried out for 12 hours using United States Pharmacopoeia (USP) paddle-type dissolution apparatus (Apparatus 2) in phosphate buffer (pH 6.8). The results of dissolution studies indicated that formulations containing Methocel K100 MCR showed better dissolution properties compared to formulaitons containing Methocel K15 MCR.It was found that Hydrophilic polymers showed better released profile than the hydrophobic polymers. Seller Inventory # 9783847346067
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Akhter Dewan TaslimaDewan Taslima Akhter has obtained her BPharm (Hons.) and MS degree from Jahangirnagar University. Naz H. Huda is graduated from Khulna University and obtained MS degree from United Kingdom. Tajnin Ahmed has obtain. Seller Inventory # 5511601
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