Synthesis, structure & bioactivity of organotin(IV)hydrazone compounds: Synthesis and biological studies of organotin(IV) complexes of pyruvic acid phenylhydrazone with thiocyanate co-ligand - Softcover

Affan, M. A.; Salam, M. A.

Softcover

ISBN 10: 3848405695 ISBN 13: 9783848405695

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

The reaction of pyruvic acid phenylhydrazone [HPAPD, (1)] with organotin(IV) chloride(s) yielded the organotin(IV) complexes (2-11). Molecular structural assessments of the complexes (2-11) have been based on data from UV-Vis, IR, 1H and 13C NMR spectral studies. The molecular structure of HPAPD (1) has also been determined by X-ray diffraction. Spectroscopic data suggested that HPAPD (1) is coordinated to the tin(IV) atom via carboxylate-O and azomethine-N atoms and acted as a mononegative bidentate chelating agent in all the organotin(IV) complexes (2-11). Spectral data indicated that thiocyanate group is N-coordinated to the Sn(IV) ion in the complexes (7-9). The coordination number of tin in all the organotin(IV) complexes (2-11) is five. The cytotoxicity of the compounds 1-11 was studied against Artemia salina. The free ligand (1) and its organotin(IV) complexes (2-11) were assayed for in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Enterobacter aerogenese, Escherichia coli and Salmonella typhi. The biological studies showed that all organotin(IV) complexes (2-11) are more potent antibacterial and cytotoxic agents than their free ligand (1).

About this title

About the Author

Dr. M. A. Affan is an Associate Professor in the Department of Chemistry, Universiti Malaysia Sarawak. He is a guest editor of OJIC. M. A. Salam is a PhD research student in the Department of Chemistry, Universiti Malaysia Sarawak. Their research interests are in the field of Organometallic Chemistry.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3848405695
• ISBN 13: 9783848405695
• Binding: Paperback
• Number of pages: 76