An Insilico Drug Design for Rheumatoid Arthritis: Protein Arginine Deiminase 4 in Rheumatoid Arthritis - Softcover

Karunakaran, Rohini; P. S., Srikumar

Softcover

ISBN 10: 3848447150 ISBN 13: 9783848447152

Publisher: LAP LAMBERT Academic Publishing, 2012

Synopsis

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting ~1% of the worldwide population. Recent biochemical and genetic evidence has strongly suggested that a dysregulated protein arginine deiminase (PAD) activity, in particular protein arginine deiminase 4 (PAD4) contributes to the onset and progression of RA. PAD4 is a transcriptional co-regulator that catalyzes the calcium-dependent conversion of specific arginine residues in proteins to citrulline. The role of PAD4 in RA leads to be a potential therapeutic target for the treatment of RA. Through insilico structure based drug design for PAD4 of Homo sapiens, the amide derivatives confirmed the binding affinity with the active sites of PAD4. The molecular docking analysis showed H bonding interactions between active sites of PAD4 and atoms of lead 3 and lead 8 of amide derivatives.

About this title

About the Author

K.Rohini is a Lecturer in the Faculty of Medicine, AIMST University, Malaysia. Though teaching biochemistry is her passion she holds a Masters in Clinical Microbiology, Bachelors in Education and Post Graduate Diplomas in Forensic Science and Bioinformatics. She has published papers on Bioinformatics & Nanotechnology.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2012
• Language: English
• ISBN 10: 3848447150
• ISBN 13: 9783848447152
• Binding: Paperback
• Number of pages: 72