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Synopsis
Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM.
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
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LAP LAMBERT Academic Publishing Feb 2014, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM. 256 pp. Englisch. Seller Inventory # 9783848487530
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Karsy MichaelMichael received his B.S. with honors in Neuroscience from the University of California - Los Angeles and then then attended New York Medical College where he completed a combined MD/PhD degree. Currently he is a reside. Seller Inventory # 5526405
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Condition: New. Print on Demand pp. 256 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. Seller Inventory # 132778183
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
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ISBN 10: 3848487535
ISBN 13: 9783848487530
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Taschenbuch. Condition: Neu. The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma | Michael Karsy | Taschenbuch | 256 S. | Englisch | 2014 | LAP LAMBERT Academic Publishing | EAN 9783848487530 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Seller Inventory # 105425830
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
Published by
LAP LAMBERT Academic Publishing Feb 2014, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 256 pp. Englisch. Seller Inventory # 9783848487530
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
Published by
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Condition: New. PRINT ON DEMAND pp. 256. Seller Inventory # 18127776530
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The Role of p53 in the Regulation of Cancer Stem Cells of Glioblastoma
Published by
LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Glioblastoma (GBM) is the most common primary brain tumor and yields a poor prognosis despite current surgical, radiological and chemotherapeutic regimens. Recent studies have provided evidence that the presence of cancer stem cells (CSC) may be responsible for GBM regrowth, dissemination and resistance to therapy. Various genetic abnormalities have been observed in GBM, such as loss of PTEN and NF1, EGFR amplification, as well as p53 mutation, which may be involved in the regulation of CSCs in GBM. This book showed that a codon-specific p53 mutation is associated with the tumorigenesis of GBM as well as regulation of CSC self-renewal and differentiation. In addition, the PTEN/AKT/mTOR and Ras/ERK1/2 signaling pathways are associated with gliomagenesis. Lastly, GBM cells are affected by therapeutic agents, including inhibitors of mTOR, PI3K and ERK1/2, along with arsenic trioxide (ATO) and all- trans retinoic acid (ATRA). The findings of this study highlight the significance of mutant p53, the role of the MAPK and mTOR signaling pathways in the regulation of CSCs, as well as the potential of ATO and ATRA as targeted treatments of GBM. Seller Inventory # 9783848487530
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The Role of P53 in the Regulation of Cancer Stem Cells of Glioblastoma
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LAP Lambert Academic Publishing, 2014
ISBN 10: 3848487535
ISBN 13: 9783848487530
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paperback. Condition: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book. Seller Inventory # ERICA82338484875356
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