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Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation - Softcover
Synopsis
The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HPβ-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HPβ-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HPβ-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HPβ-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.
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About the Author
Lokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.He has five years of research experience in controlled and targetted drug delivery.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 384849390X
- ISBN 13 9783848493906
- BindingPaperback
- LanguageEnglish
- Number of pages120
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Enhancement of complexation of drug: binary and ternary mixtures
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LAP LAMBERT Academic Publishing Apr 2012, 2012
ISBN 10: 384849390X
ISBN 13: 9783848493906
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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP -CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP -CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP -CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP -CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability. 120 pp. Englisch. Seller Inventory # 9783848493906
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Enhancement of complexation of drug: binary and ternary mixtures : Bhati et al. enhancement of complexation
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 384849390X
ISBN 13: 9783848493906
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Taschenbuch
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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP -CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP -CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP -CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP -CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability. Seller Inventory # 9783848493906
Quantity: 1 available
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Enhancement of complexation of drug: binary and ternary mixtures
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 384849390X
ISBN 13: 9783848493906
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Bhati Lokesh KumarLokesh bhati is presently a research scientist in mankind research laboratory, gurgaon, India. He is presently the reviewer of many indexed journals. He has many publications in national and international journals.H. Seller Inventory # 5526893
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Enhancement of complexation of drug: binary and ternary mixtures
Published by
LAP LAMBERT Academic Publishing Apr 2012, 2012
ISBN 10: 384849390X
ISBN 13: 9783848493906
New
Taschenbuch
Seller: buchversandmimpf2000, Emtmannsberg, BAYE, Germany
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Taschenbuch. Condition: Neu. Neuware -The study demonstrated the possibility of significantly improving the dissolution performance of MX by simultaneous complexation with cyclodextrin. The importance of proper selection of the most suitable counter ion to adequately improve the cyclodextrin - complexation efficiency has been pointed out. PVP showed a synergistic effect when used in combination with HP¿-CD. Phase solubility experiments demonstrated that the ternary system with PVP (pH 5.8) exhibited a stability constant 12.9 times greater than the binary complex. The drug solubility in the presence of 50mM HP¿-CD was about 6.23 times higher than that in the binary system. Results confirmed that the strong increase in the drug solubility shown by HP¿-CD ternary system with PVP. Solid state demonstrated that freeze drying technique was suitable for obtaining solid homogeneous equimolar MX-HP¿-CD-PVP complexes. These systems could be useful for formulating fast-dissolving drug solid dosage form able to assure rapid onset of analgesic action and improved bioavailability.Books on Demand GmbH, Überseering 33, 22297 Hamburg 120 pp. Englisch. Seller Inventory # 9783848493906
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Enhancement of complexation of drug: binary and ternary mixtures: Bhati et al. enhancement of complexation
Published by
LAP LAMBERT Academic Publishing, 2012
ISBN 10: 384849390X
ISBN 13: 9783848493906
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