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SUSTAINED RELEASE MICROPARTICULATE DELIVERY SYSTEM OF INTERFERON-¿-2B: Microparticulate Drug Delivery For Ovarian Cancer - Softcover

 
9786206791058: SUSTAINED RELEASE MICROPARTICULATE DELIVERY SYSTEM OF INTERFERON-¿-2B: Microparticulate Drug Delivery For Ovarian Cancer
  • PublisherLAP LAMBERT Academic Publishing
  • Publication date2023
  • ISBN 10 620679105X
  • ISBN 13 9786206791058
  • BindingPaperback
  • LanguageEnglish
  • Number of pages88

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Monika Gulia
ISBN 10: 620679105X ISBN 13: 9786206791058
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The encapsulation mechanism of \*rINF- -2b in lipid, carbohydrate and protein based microspheres to achieve high encapsulation efficiency and protein loading capacity. \*rINF- -2b is a fragile molecule and encapsulation requires in addition the preservation of their structural integrity and functionality. We estimated that \*rINF- -2b-Pt-GMs-15 offered sustained release of protein over two weeks and released 95.01±4.23% of \*rINF- -2b. The stability study assessment by gel electrophoresis and circular dichroism confirmed post translation structural integrity of \*rINF- -2b in \*rINF- -2b-Pt-GMs-15 nanoformulation. In vitro therapeutic efficacy testing of optimized formulation further provided compelling evidence with enhanced cytotoxicity and low IC50 in SKOV3 cells. Therefore protamine sulphate coated microspheres may potentially be used for sustained delivery of \*rINF- -2b and warrants in depth in vivo study to scale up the technology for clinical intervention. 88 pp. Englisch. Seller Inventory # 9786206791058

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Monika Gulia
Published by LAP LAMBERT Academic Publishing, 2023
ISBN 10: 620679105X ISBN 13: 9786206791058
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Seller: AHA-BUCH GmbH, Einbeck, Germany

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Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The encapsulation mechanism of \*rINF- -2b in lipid, carbohydrate and protein based microspheres to achieve high encapsulation efficiency and protein loading capacity. \*rINF- -2b is a fragile molecule and encapsulation requires in addition the preservation of their structural integrity and functionality. We estimated that \*rINF- -2b-Pt-GMs-15 offered sustained release of protein over two weeks and released 95.01±4.23% of \*rINF- -2b. The stability study assessment by gel electrophoresis and circular dichroism confirmed post translation structural integrity of \*rINF- -2b in \*rINF- -2b-Pt-GMs-15 nanoformulation. In vitro therapeutic efficacy testing of optimized formulation further provided compelling evidence with enhanced cytotoxicity and low IC50 in SKOV3 cells. Therefore protamine sulphate coated microspheres may potentially be used for sustained delivery of \*rINF- -2b and warrants in depth in vivo study to scale up the technology for clinical intervention. Seller Inventory # 9786206791058

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Gulia, Monika
Published by LAP Lambert Academic Publishing, 2023
ISBN 10: 620679105X ISBN 13: 9786206791058
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Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The encapsulation mechanism of *rINF- -2b in lipid, carbohydrate and protein based microspheres to achieve high encapsulation efficiency and protein loading capacity. *rINF- -2b is a fragile molecule and encapsulation requires in addition the preservation o. Seller Inventory # 1240487977

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