UV Spectroscopic Method and Method Validation of Methylphenidate: UV Spectroscopic Method and Method Validation of Methylphenidate in Bulk and Marketed Dosage Form Economically - Softcover

Choudhury, Tirthankar; Chaurasiya, Jay; Gupta, Ashwani

 
9786207488346: UV Spectroscopic Method and Method Validation of Methylphenidate: UV Spectroscopic Method and Method Validation of Methylphenidate in Bulk and Marketed Dosage Form Economically
Softcover
ISBN 10: 6207488342 ISBN 13: 9786207488346
Publisher: LAP LAMBERT Academic Publishing, 2024

Synopsis

This UV-spectrophotometric technique is quite simple, accurate, precise,reproducible, and sensitive. The UV method has been developed for quantification of Methylphenidate in tablet formulation. It involves absorbance measurement at 288 nm (ʎmax of Methylphenidate) in Ethanol and distilled water (89:11) ratio. For the UV Spectrophotometric method, linearity was obtained in a concentration range of 1-50µg/ml for methylphenidate and with a regression value of 0.9998. Recovery was found in the range of 98-101%. The standard deviation and % RSD were found to be < 2 %. It showed the high precision of the method, in accordance with ICH guidelines. The method has been successively applied to active pharmaceutical ingredients and was validated according to ICH guidelines. The method is highly accurate, reproducible and economical.

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Publisher
LAP LAMBERT Academic Publishing
Publication date
2024
Language
English
ISBN 10 
6207488342
ISBN 13 
9786207488346
Binding
Paperback
Number of pages
72