SOLID DISPERSIONS – AN APPROACH TO ENHANCE THE DISSOLUTION RATE - Softcover

Nagam, Santhi Priya; Pusuluri, Siva Krishna; Thalla, Sreenu

Softcover

ISBN 10: 6208424445 ISBN 13: 9786208424442

Publisher: LAP LAMBERT Academic Publishing, 2025

Synopsis

Oxcarbazepine, 10, 11-dihydro- 10-oxo- 5H-dibenz(b,f)azepine- 5-carboxamide, is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. It is also used to treat anxiety and mood disorders, and benign motor tics. Oxcarbazepine is marketed as Trileptal by Novartis and available in some countries as a generic drug. It is a prodrug which is activated to eslicarbazepine in the liver. It is a white or yellowish-white, crystalline powder; almost odourless, with a molecular weight of 252.268 g/mol. Oxcarbazepine is slightly soluble in acetone, chloroform, dichloromethane, and methanol. It is practically insoluble in ethanol, ether, and water. The drug exhibits low bioavailability related to its poor water solubility. Oxcarbazepine is a class II compound, i.e., water-insoluble, lipophilic, and highly permeable according to Biopharmaceutical Classification System. The purpose of this study was to prepare and characterize solid dispersions of the poor water soluble anticonvulsant with water soluble carrier such as primogel to improve its dissolution properties. The solid dispersions were prepared by co-grinding and solvent evaporation method.

Edition details

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2025
• Language: English
• ISBN 10: 6208424445
• ISBN 13: 9786208424442
• Binding: Paperback
• Number of pages: 72