Items related to NON-NEURONAL CELLS IN ALZHEIMER'S DISEASE
Synopsis
Alzheimer's disease (AD) is a devastating pathology of the central nervous system (CNS) of unknown etiology which represents the most common neurodegenerative disorder. AD is the major cause of senile dementia, affecting approximately 5% of the population over 70. This syndrome is characterized by loss of short-term memory and progressive impairment of intellectual functions. No established therapeutic strategy has been found so far.Until recently, much of the literature on AD discussed the effects of this syndrome on the CNS. In the last few years, however, a large amount of information has appeared which underscored the importance of studying AD from other perspectives with the view of identifying reliable biological markers. The amyloid precursor proteins (APPs), for instance, constitute a complex family of membrane-bound and soluble glycoproteins that are derived by alternative splicing of a gene on chromosome 21. In the hemopoietic system, APPs have been detected in a number of cell types, such as leukocytes, megakaryocytes and platelets. In addition plasma contains picomolar concentrations of APP isoforms most likely derived from platelets. Abnormalities were also detected in the electrophoretic profile of erythrocytic membranes from AD patients. Numerous abnormalities have been proposed as peripheral markers for AD and several laboratories around the world are deeply involved in this challenging research.This book provides up-to-date information, as review chapters, on non-neuronal cells, with the aim of stimulating the formulation of potential diagnostic-therapeutic strategies.
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Review
... the chapters are well written and informative ... the book is well organized and will be of interest to a wide audience. --Journal of Chemical Neuroanatomy
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- PublisherWorld Scientific Publishing Company
- Publication date1995
- ISBN 10 9810220928
- ISBN 13 9789810220921
- BindingHardcover
- LanguageEnglish
- Number of pages252
- EditorZatta Paolo, Nicolini M
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Non-Neuronal Cells in Alzheimer's Disease
Published by
World Scientific Pub Co Inc, 1995
ISBN 10: 9810220928
ISBN 13: 9789810220921
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Non-Neuronal Cells in Alzheimer's Disease
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World Scientific Publishing Co Pte Ltd, 1995
ISBN 10: 9810220928
ISBN 13: 9789810220921
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Non-Neuronal Cells in Alzheimer's Disease
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World Scientific Publishing Company, Incorporated, 1995
ISBN 10: 9810220928
ISBN 13: 9789810220921
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Non-Neuronal Cells in Alzheimer's Disease
Published by
World Scientific Publishing Company, Incorporated, 1995
ISBN 10: 9810220928
ISBN 13: 9789810220921
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Non-Neuronal Cells in Alzheimer's Disease
Published by
World Scientific Publishing Company, Incorporated, 1995
ISBN 10: 9810220928
ISBN 13: 9789810220921
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Non-Neuronal Cells in Alzheimer*s Disease
Published by
World Scientific Pub Co Inc, 1995
ISBN 10: 9810220928
ISBN 13: 9789810220921
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