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The book is broadly divided into two parts. The first part presents the "basic science" of nanoindentation including the background of contact mechanics underlying indentation technique, and the instrumentation used to gather mechanical data. Both the mechanics background and the instrumentation overview provide perspectives that are optimized for biological applications, including discussions on hydrated materials and adaptations for low-stiffness materials. The second part of the book covers the applications of nanoindentation technique in biological materials. Included in the coverage are mineralized and nonmineralized tissues, wood and plant tissues, tissue-engineering substitute materials, cells and membranes, and cutting-edge applicationsat molecular level including the use of functionalized tips to probe specific molecular interactions (e.g. the ligand-receptor binding). The book concludes with a concise summary and an insightful forecast of the future highlighting the current challenges.
Michelle L. Oyen is a Lecturer in Mechanics of Biological Materials in the Mechanics and Materials Division and the Engineering for the Life Sciences group in the Cambridge University Engineering Department. She holds a BS degree in Materials Science and Engineering and an MS Degree in Engineering Mechanics, both from Michigan State University, and a PhD degree in Biophysical Sciences and Medical Physics from the University of Minnesota. She joined Cambridge Engineering in 2006 following an appointment as Research Scientist at the University of Virginia Center for Applied Biomechanics. She is a member of the Materials Research Society and the ASME Bioengineering Division, a principal editor for the Journal of Materials Research, a moderator of iMechanica and a founding committee member for the new UK-based bioengineering society.
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