APOPTOSIS IN HEALTH AND DISEASE : CLINICAL AND THERAPEUTIC ASPECTS
MARTIN HOLCIK,ERIC C. LACASSE,ALEX E. MACKENZIE,ROBERT G. KORNELUK
ISBN 10: 0521529565 ISBN 13: 9780521529563
Published by Cambridge University Press, 2005
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Synopsis:
The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states.
Book Description: Programmed cell death or apoptosis is centrally involved in the pathogenesis of many significant human illnesses and injury states, including cancer, autoimmune disease, psoriasis, and other degenerative conditions. This 2005 book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies.
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Bibliographic Details
Title: APOPTOSIS IN HEALTH AND DISEASE : CLINICAL ...
Publisher: Cambridge University Press
Publication Date: 2005
Binding: Hardcover
Condition: Brand New