Adenovirus Receptor Interactions | Structural Basis of Adenovirus Attachment to its Receptor CD46

David Persson

ISBN 10: 3639189841 / ISBN 13: 9783639189841

Published by VDM Verlag Dr. Müller, 2009

About this Item

Adenovirus Receptor Interactions | Structural Basis of Adenovirus Attachment to its Receptor CD46 | David Persson | Taschenbuch | Englisch | VDM Verlag Dr. Müller | EAN 9783639189841 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 101491983

Bibliographic Details

• Title: Adenovirus Receptor Interactions | Structural Basis of Adenovirus Attachment to its Receptor CD46
• Publisher: VDM Verlag Dr. Müller
• Publication Date: 2009
• Language: English
• ISBN 10: 3639189841
• ISBN 13: 9783639189841
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

Adenoviruses are common human pathogens causing a number of infectious diseases. They have been found in virtually all organs, producing symptoms ranging from the common cold to pneumonia. Additionally, they also cause a variety of clinical symptoms such as epidemic keratoconjunctivitis, pharyngoconjunctival fever, infantile gastroenteritis, cystitis and urinary tract infections. Individuals with a poorly functioning immune systems are especially prone to severe life-threatening infections. In 1977 Philip Sharp and Richard Roberts discovered the ability of Adenoviruses to split genes, and were in 1993 awarded the Nobel Prize in Physiology and Medicine for their discovery. Today, Adenoviruses are mostly studied for the ability to be used as delivery vehicles in gene therapy. We here studied Adenoviruses binding to the cellular receptor CD46, characterizing the binding mechanism at an atomic level. We used a combination of biological and biochemical methods connecting structure and function to define the Adenovirus interaction with CD46. Our work will have implications for drug design, focusing on reducing Adenovirus complications during organ transplantation.

About the Author

B. David Persson, Bachelorn in Biochemistry at the University of Umea 2003, Masters in Molecular Biology at the University of Umea 2004, PhD in Structure Biology at the University of Tuebingen 2008.