An international corps of expert investigators describe their optimized techniques for both the identification of new cell adhesion proteins and for the characterization of novel adhesive structures. Their cutting edge methods will enable both novice and experienced researchers readily to identify and clone new adhesion proteins, to successfully produce inhibitors of the adhesive activity, to develop biological models for the assay of cell-to-matrix and cell-to-cell adhesion in vitro, and to measure the signaling activities of adhesion proteins. By illuminating these adhesive molecules and the possibilities for manipulating them, the new experimental strategies collected here will have considerable clinical potential for the regulation of immunity, inflammation, tissue remodeling, and embryonic development.

Review

"I think this book presents an excellent manual not only for beginning graduate students, who can find a variety of basic techniques, but also for experienced researchers who are new in the field of endothelial biology. . .a very useful manual, containing almost every technique dealing with the cell adhesion properties of the endothelium."-Doody's Health Sciences Book Review Journal

"Dejana and Corada have assembled a wide range of chapters covering methods used for the study of adhesion proteins. The individual chapters are generally well written, and most of the methods that would be expected in such a volume are covered."-Cell Biology International

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