Adhesive Interactions in Normal and Transformed Cells

Rovensky, Yury A.

ISBN 10: 1617793035 / ISBN 13: 9781617793035

Published by Humana, 2011

About this Item

This book describes the basic mechanisms that allow tissue cells to attach to each other and to the extracellular matrix. Includes comprehensive data on structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells. Num Pages: 225 pages, biography. BIC Classification: MJCL; PSF. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 21. Weight in Grams: 634. . 2011. 2012th Edition. hardcover. . . . . Books ship from the US and Ireland.

Seller Inventory # V9781617793035

Bibliographic Details

• Title: Adhesive Interactions in Normal and Transformed Cells
• Publisher: Humana
• Publication Date: 2011
• Language: English
• ISBN 10: 1617793035
• ISBN 13: 9781617793035
• Binding: Hardcover
• Condition: New

About this title

Synopsis

Adhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces. 

Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.

About the Author

Yury A. Rovensky,  M.D., Ph.D., D.Sc.

1980-2002   Leading Researcher; Institute of Carcinogenesis, Cancer Research Center, Moscow, Russia.  

 Research interests: 
 Normal and tumor cell biology, cell behavior:
1.       Contact interactions of normal and tumor cells with the extracellular matrix; the intercellular contact interactions.
2.        The locomotion of normal and cancer cells.
3.    Topographical cell responses: morphogenetic responses of normal and cancer cells to the topography  (geometrical configuration) of  the extracellular matrix surfaces;
4.       Scanning electron microscopy of normal and tumor cells.
5.       Cell surface morphology.

      Yury.A.Rovensky is the author or a co-author of publications including 77 full-length journal papers, 1 book and chapters in 3 books. 


Book: 
          Rovensky Yu.A.  «Scanning Electron Microscopy of Normal and Tumor Cells», Meditsina, Moscow, 152p   (1979).  
                                                        
Chapters in Books : 
      1. Rovensky, Yu.A.  «Methodological Bases of Biological Material Preparation for Scanning Electron   Microscopy» In: "Atlas of Scanning Electron Microscopy of Cells, Tissues and Organs".
Meditsina,  Moscow, pp12-20 (1987).
    2.   Rovensky,Yu.A.  «Cell Surface Morphology in vitro». In: "Atlas of Scanning Electron Microscopy of  Cells, Tissues and Organs".  Meditsina, Moscow, pp30-37 (1987).     
    3. Rovensky, Yu.A. & Vasiliev, J.M.  «Morphogenetic Cell Reactions and their Disturbances under the Neoplastic Transformation». In: "Carcinogenesis". Scientific World, Moscow,  pp.260-283 ( 2000 - 1st edition);  pp.376-414 (2004 - 2d edition updated).  
    4. Rovensky Yu.A. " The Cell Adhesion Interaction Disturbances are the Basis of the Abnormal Behavior of  Cancer Cells". In: "Clinical Oncohematology: a Manual for  Physicians".  Meditsina,  Moscow, pp.141-156 (2007 - 2d edition updated).