Advanced Fragmentation Methods in Biomolecular Mass Spectrometry: Probing Primary and Higher-order Structure With Electrons, Photons and Surfaces

Breaking down large biomolecules into fragments in a controlled manner is key to modern biomolecular mass spectrometry. This book is a high-level introduction, as well as a reference work for experienced users, to ECD, ETD, EDD, NETD, UVPD, SID, and other advanced fragmentation methods. It provides a comprehensive overview of their history, mechanisms, instrumentation, and key applications. With contributions from leading experts, this book will act as an authoritative guide to these methods.
Aimed at postgraduate and professional researchers, mainly in academia, but also in industry, it can be used as supplementary reading for advanced students on mass spectrometry or analytical (bio)chemistry courses.

Frederik Lermyte is an Assistant Professor of Conformation-Sensitive Mass Spectrometry at the Technical University of Darmstadt. He studied Chemistry at the University of Antwerp, and completed his PhD in 2016. His PhD work focused on the use of ion mobility spectrometry and advanced (predominantly electron-based) fragmentation methods in structural biology. He subsequently worked as a Research Fellow at the University of Warwick for three years, where he used ultrahigh-resolution tandem MS and synchrotron spectromicroscopy to study the role of metals in neurodegeneration, and as a postdoctoral researcher at the University of Liège, before moving to Darmstadt. His research interests include fundamental and applied aspects of native MS, top-down protein analysis, and ion mobility spectrometry.