Advanced Glycation Inhibitory Potential of Certain Antidiabetic Plants

The present study was designed to investigate the antiglycation potential of hydro-alcoholic and alkaloidal fractions of selected plants. Seeds of Trigonella foenum-graecum, bulbs of Allium sativum, fruits of Momordica charantia. and leaves of Gymnema sylvestre were selected. The protein glycation inhibitory activity of these plants was evaluated using glucose-bovine serum albumin assay. Among the hydroalcoholic extracts, Trigonella-foenum graecum showed highest antiglycation activity (IC50 = 53.53 ± 1.24 µg/ml) followed by Allium sativum (IC50 = 68.36 ± 1.56 µg/ml), Momordica charantia (IC50 = 85.16 ± 1.87 µg/ml) and Gymnema sylvestre (IC50 = 103.66 ± 2.09 µg/ml). Among the alkaloidal fractions, the highest antiglycation activity was shown by Trigonella-foenum graecum (IC50 = 31.56 ± 1.36 µg/ml) followed by Allium sativum (IC50 = 40.46 ± 1.59 µg/ml), Momordica charantia (IC50 = 54.8 ± 2.12 µg/ml) and Gymnema sylvestre (IC50 = 64.50 ± 1.73 µg/ml). Aminoguanidine, a standard drug, showed 100% inhibition (IC50 = 22.45 ± 1.89 µg/ml). Alkaloidal extracts of these plants possess antiglycation activity and may be explored in diabetic complications

The author is Assistant professor in Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala. He has 11 years of experience of teaching and Research.His keen area of interest are neuropathic pain, stress adaptation and diabetic complications.