This issue of the Heart Failure Clinics, edited by Drs. James Fang and Michael Givertz, is entitled "Advanced Heart Failure" and covers a wide array of topics relating to the subject. The issue will delve into the prevalence, history and prognosis of advanced heart failure; cardiorenal interactions; cardiohepatic interactions; the role of temporary mechanical circulatory support; guided therapy; the role of heart transplantation; palliative care; frailty; and novel biological techniques, among other topics.

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