Advances in Swine in Biomedical Research

Mike E. Tumbleson

ISBN 10: 0306454955 / ISBN 13: 9780306454950

Published by Springer US, Springer New York, 1997

About this Item

Druck auf Anfrage Neuware - Printed after ordering - Contains papers from the October 1995 symposium, in sections on general aspects, transgenics, and immunology and infectious diseases. Topics include ultrastructure of the liver in piglets fed dietary oils, artificial surfactant as a vehicle for endotracheal epinephrine in pediatric porcine cardiopul.

Seller Inventory # 9780306454950

Bibliographic Details

• Title: Advances in Swine in Biomedical Research
• Publisher: Springer US, Springer New York
• Publication Date: 1997
• Language: English
• ISBN 10: 0306454955
• ISBN 13: 9780306454950
• Binding: Buch
• Condition: Neu
• Dimensions: 240W x 161H x 31D millimeters 240 millimeters width by 161 millimeters height by 31 millimeters depth
• Weight: 857 grams

About this title

Synopsis

Similarities in structure and function between pigs and human beings include size, feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmo­ nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory rates, tidal volumes and social behaviors. Since the pig is an omnivore, it provides an adaptable model to evaluate chronic and acute exposures to xenobiotics such as alcohoL caffeine, tobacco, food additives and environmental pollutants. Swine have been used successfully as models to evaluate alcoholism, diabetes, absorption, digestion, total paren­ teral nutrition, organ transplantation, atherosclerosis, exercise, hypertension. hemorrhagic hypotension, melanoma, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal healing and septic shock. A severe and worsening shortage of organs and tissues for transplantation in patients with severe organ failure has encouraged the consideration of inter species or xenotransplan­ tation. In developing programs toward this end, the pig generally is viewed as the preferred donor because of its size, physiology and availability. The pig harbors relatively few diseases which could be transmitted inadvertently to human patients. The ability to genetically modify swine to ameliorate the consequences of the human immune response offers a further significant advantage. Another important consideration for an animal model is that basic biologic back­ ground information be available for investigators to design future prospective studies.