Alexander Disease
Language: English
Published by Morgan & Claypool Life Sciences, 2017
- Softcover
- New
Condition: New
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Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Über den AutorAlbee Messing, V.M.D., Ph.D., is Professor of Neuropathology in the Department of Comparative Biosciences, and the Director of the Waisman Center (an international center dedicated to research, education, and clinical .
Seller Inventory # 448166763
- Title
- Alexander Disease
- Author
- Messing, Albee
- Publisher
- Morgan & Claypool Life Sciences
- Publication year
- 2017
- Condition
- New
- Binding
- Soft cover
- Language
- English
- ISBN 10
- 1615047581
- ISBN 13
- 9781615047581
This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord.
Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood.
Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning.
We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis.
GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact.
Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.
"Synopsis" may belong to another edition of this title.
About the Author
Professor Alexei Verkhratsky, MD, PhD, D.Sc., Member of Academia Europaea, Member of the German National Academy of Sciences Leopoldina, Member of Real Academia Nacional de Farmacia (Spain), was born in 1961 in Stanislaw, Galicia, Western Ukraine. He graduated from Kiev Medical Institute in 1983, and received his PhD (1986) and D.Sc. (1993) in Physiology from Bogomoletz Institute of Physiology, Kiev, Ukraine. He joined the Division of Neuroscience, School of Biological Sciences in Manchester in September 1999, became a Professor of Neurophysiology in 2002, and served as Head of the Division from 2002 to 2004. From 2007 to 2010 he was appointed as visiting professor/Head of Department of Cellular and Molecular Neurophysiology at the Institute of Experimental Medicine, Academy of Sciences of Czech Republic. In 2010 A. Verkhratsky was appointed as a Research Professor of Ikerbasque (the Basque Research Council), in 2011 as an Honorary Visiting Professor at Kyushu University, Fukuoka, Japan and since 2012 has acted as Adjunct Scientific Director of the Achucarro Basque Centre for Neuroscience (Bilbao, Spain). Prof. A. Verkhratsky is a co-editor-in-chief of Cell Calcium (2000), and Membrane Transport & Signalling - Wiley Interdisciplinary Reviews (2009), Receiving Editor of Cell Death & Disease (2009), and a member of editorial boards of numerous scientific journals.
Prof. Alexei Verkhratsky is an internationally recognised scholar in the field of cellular neurophysiology. His research is concentrated on the mechanisms of inter- and intracellular signalling in the CNS, being especially focused on two main types of neural cells, neurones and neuroglia. He made important contributions to understanding the chemical and electrical transmission in reciprocal neuronal-glial communications and on the role of intracellular Ca2+ signals in the integrative processes in the nervous system. Many of A. Verkhratsky's studies are dedicated to investigations of cellular mechanisms of neurodegeneration. In recent years he studies the glial pathology in Alzheimer disease. He authored a pioneering hypothesis of astroglial atrophy as a mechanism of neurodegeneration.
Vladimir Parpura, M.D., Ph.D., holds both a medical degree, awarded from the University of Zagreb in Croatia in 1989, and a doctorate in Neuroscience and Zoology from Iowa State University in 1993. He has held faculty appointments at the Department of Zoology and Genetics, Iowa State University, and the Department of Cell Biology and Neuroscience, University of California Riverside. He is presently a tenured Associate Professor in the Department of Neurobiology, University of Alabama Birmingham, as well as a tenured Full Professor in the Department of Biotechnology, University of Rijeka, Croatia. He was elected as a Member of Academia Europaea (MEA) in 2012. His current research includes: i) studying the modulation of calcium-dependent glutamate release from astrocytes in health and disease; ii) visualization of vesicular/receptor trafficking; iii) examination of the nature and energetics of interactions between exocytotic proteins using single molecule detection approaches; iv) development of scaffolds and dispersible materials, most notably modified carbon nanotubes, which can be used in repair after brain injury and v) bio-mimetic micro-robotics. He has been interfacing neuroscience with nanoscience/nanotechnology, synthetic biology and biomedical engineering.
"About the title" may belong to another edition of this title.
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