Allogeneic Stem Cell Transplantation

Case Western Reserve Univ., Cleveland, OH. Text, for clinicians, presents a concise review of new developments, new findings on the kinetics of immune reconstruction, decision-tree analyses, and more. Comprehensive and current information on best clinical practice is included. DNLM: Hematopoietic Stem Cell Transplantation.

Allogeneic transplantation has dramatically grown in importance as a curative cellular therapy for patients with hematologic malignancies and selected solid tumors, marrow failure disorders, and inherited metabolic diseases. In Allogeneic Stem Cell Transplantation: Clinical Research and Practice, internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-vs-host disease. They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of non-myeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.
Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice offers both clinicians and researchers concise advice on today's best clinical practice, as well as insightful analysis of the promising new lines of laboratory research that are leading to safer and more effective allogeneic transplant procedures.