Analysis of Amyloid Using Various Methods

Language: English

Published by Springer Mär 2026, 2026

3031707168 / 9783031707162

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -This book explores the world of amyloid, consisting of heterogeneous deposits that have captivated scientists for decades. Amyloid, characterized by its highly organized insoluble protein fibrils exhibiting cross-layered quaternary beta-sheet structures, comprises diverse components such as the P-component, sialic acid, O-acyl sialic acid, and sGAG components. This assembly forms an anisotropic entity that induces birefringence in linearly polarized light, creating a distinctive optical signature.Initially linked to human disease and tissue damage, the predominant idea that amyloid only harms the host has been challenged. Recent pioneering studies have uncovered the existence of functional amyloid fibers in unexpected domains, from bacteria to mammals.Advances during the 1960s and 1970s, along with seminal immunohistochemical investigations, gave impetus to immunobiological analysis of amyloid in the 1980s. Notable work, such as the exploration of amyloid fiber staining techniques and the comprehensive study of histochemical properties, have enriched the understanding of this enigmatic deposit.The book presents a current overview of amyloid research in health and disease, with contributions from the prestigious biennial Amyloid Forum. Written by a distinguished researcher with nearly five decades of experience, the book encompasses five meticulously elaborated chapters.From human and animal deposits to bacterial formations, isolated fibrils, prions, and amyloid-related neurodegenerative disorders, each category of deposit is given a thorough examination. Innovative topo-optical staining techniques - polarization microscopy, fluorescence microscopy and confocal laser scanning fluorescence microscopy - reveal intricate structures in all species. Coherent structural features are authenticated by various staining reactions and different digestions.A key segment dissects animal prion fibers, revealing their intricate architecture by topo-optical reactions and uncovering selective arrangements of components.To complete this, the book confirms the postulated helical structure of the amyloid fiber. This innovative idea is validated by laser scanning confocal fluorescence microscopy, which reveals ordered and helically stacked amyloid protein fibrils in beta-sheet conformation. Associations with chondroitin, heparan sulfate, and looser sphingolipid linkages further unravel the structural complexities of amyloid. Also offers an insightful journey into the realm of amyloid, combining historical knowledge with cutting-edge methodologies, redefining the understanding of this intricate phenomenon. 316 pp. Englisch.…

Seller Inventory # 9783031707162

Title
Analysis of Amyloid Using Various Methods
Author
Josef Makovitzky
Publisher
Springer Mär 2026
Publication year
2026
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3031707168
ISBN 13
9783031707162
Item weight
482 grams
Dimensions
235x155x18 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany