Analytical Method Development and Stability Studies of Carvedilol

Language: English

Published by GRIN Verlag Jun 2015, 2015

3656948895 / 9783656948896

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Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermanyBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -Master's Thesis from the year 2011 in the subject Medicine - Pharmacology, grade: 8.0, , course: B.Pharm.,M.Pharm, language: English, abstract: A reverse phase high performance liquid chromatographic method (HPLC) has been developed for the method development validation of Carvedilol in bulk and pharmaceutical formulation by using YMC PACK PRO 4.6 X 150 mm (5µm Particle size). The mobile phase was Buffer: Acetonitrile: (70:30) and pH was adjusted to 2 pumped at a flow rate of 1 ml/min and the eluents were monitored at 320nm. Linearity was obtained in the concentration range of 10-90 mig/ml. The retention time of Carvedilol was found to be 3.2 minute. The method was validated for specificity, accuracy, precision, linearity, and limit of detection, limit of quantification, robustness and solubility stability. LOD and LOQ were found to be 0.001 mig/ml and 0.011mig/ml respectively. The method was statistically validated and RSD was found to be less than 2% indicating high degree of accuracy and precision of the proposed HPLC method. Stability study report revealed that the drug is susceptible for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is stable to thermal degradation. More over the degradants were well separated from its API. Due to its simplicity, rapidness, high precision and accuracy, the proposed HPLC method may be used for determining Carvedilol in bulk drug samples or in pharmaceutical dosage forms. 84 pp. Englisch.…

Seller Inventory # 9783656948896

Title
Analytical Method Development and Stability Studies of Carvedilol
Author
Kishanta Kumar Pradhan
Publisher
GRIN Verlag Jun 2015
Publication year
2015
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
3656948895
ISBN 13
9783656948896
Item weight
135 grams
Dimensions
210x148x7 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germany

5-star seller

AbeBooks seller since January 11, 2012

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BuchWeltWeit Ludwig Meier e.K.

Germany