Analytical Methods for Tobacco and Nicotine Harm Reduction

This book presents a critical review of the analytical methods used for the measurement of harmful and potentially harmful compounds (HPHC) in tobacco and nicotine-related products. In the first chapter of the book, a presentation of the main types of tobacco products is introduced, including cigarettes, cigars, cigarillos, little filter cigars, dissolvable tobacco products, hookah (shisha or waterpipe), nicotine gels, pipe tobacco products, roll your own, smokeless tobacco products, such as dip, snuff, snus, and chewing tobacco and E-Cigarettes, vapes, and other electronic nicotine delivery systems (ENDS). In the second and main part of the book, the analytical methods for the compounds in the established list from the U.S. Food and Drug Administration (FDA) of HPHC are discussed. For example, in cigarette smoke, specific discussions related to the analytical methods for nicotine, acetaldehyde, acrolein, acrylonitrile, aromatic amines, ammonia, benzene, benzo[a]pyrene, 1,3-butadiene, carbon monoxide, crotonaldehyde, formaldehyde, isoprene, TSNA’s, and toluene are presented. Specific analytical methods for the analysis of HPHC in ENDS are also included. Various other analytical methods used for all the 93 HPHC in the established list by FDA for tobacco products and tobacco smoke are presented. The book will be useful to scientists working in the industry as well as students and researchers interested in the area.

Serban C. Moldoveanu 

Education: PhD in Chemistry, Univ. of Bucharest, Romania. Post-doc in Informatics, Univ. of Bucharest, Romania. Work history: Sr. Principal Chemist, Eurofins-Lancaster Laboratories, 2025-present, Sr. Principal Scientist, R.J. Reynolds Tobacco Co., 2014-2023; Principal Scientist, R.J. Reynolds Tobacco Co., 2004-2014; Various research and managerial positions, Brown & Williamson Tobacco Co., 1986-2004; Scientist, Dowell-Schlumberger, Tulsa OK, 1986; Visiting Assistant Professor, UGA, Athens GA, USA 1983-1985; Various teaching positions up to Associate Professor at Univ. of Bucharest, until 1982. Scientific activity: Research activity on various aspects of chromatography and pyrolysis; Over 150 publications in peer-reviewed journals, over 50 presentations at Tobacco Science Research Conference (TSRC), 8 books published in Elsevier (3 having second edition), 2 books edited in IntechOpen, and 7 other books published in different printing houses in Romanian, 13 chapters in various books; Member of the editorial board for Journal of Analytical Methods in Chemistry, Frontiers in Chemistry, and of Journal of Pharmaceutical Research and Drug Information (Hanoi); 22 Published patents/patent applications; Recipient of TSRC Lifetime Achievement Award for 2012. - h-index = 35, i10-index = 81

Robert Owen Bussey, III

Education: BA Spanish, Davidson College, 2008. PhD, Medicinal Biochemistry, University of North Carolina at Greensboro, 2014. Work History: Research Assistant, Department of Chemistry Davidson College, Summers 2005 and 2006; Teaching Assistant, Department of Chemistry, University of North Carolina at Greensboro 2009-2014; Research Scientist, (various positions up to Master Scientist) Analytical Development, Reynolds American Services Company, 2014-Present. Scientific Activity: Non-routine method development along with analytical support of product development at RAI Services Company. Publications: 12 publications from 2007-Present, ‪h-index = 3