Animal Models for Medical Countermeasures to Radiation Exposure

Reprint from Radiation Research Volume 173, pages 557-578. Some highlighting to several text pages. Topics covered include the Immune System, the Hematopoietic System; Animal Models for the Bone Marrow; Gastrointestinal Track; Lung; Kidney, Skin; Other Factors affecting Experimental Outcome; Conclusions; Acknowledgments; and References. Table 1 (Description of Radiation Pathology in Lung), Table 2 (Mammalian Animal Models Grouped by Pulmonary Subtype), Table 3 (summary of Strain-Dependent Differences in Mouse Lung); Other Factors Affecting Experimental Outcome; Conclusions; Acknowledgments; and References. Since the inception of the eight Centers for Medical Countermeasures Against Radiation, under the purview of the National Institute of Allergy and Infectious Diseases with National Cancer Institute involvement. Since a focus of these Centers is to develop agents for prophylaxis, mitigation, and treatment of radiation injury, the testing of such countermeasures inevitably requires the use of animal model systems.