Anti HIV Drugs. Non-Nucleoside Reverse Transcriptase Inhibitors: NNRTIs as Anti HIV Drugs

Literature Review from the year 2014 in the subject Chemistry - Other, , language: English, abstract: The proposed book entitled, "Anti HIV Drugs: Non-Nucleoside Reverse Transcriptase Inhibitors" gives an outline of the Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI) class of Anti HIV drugs, from the initial discovery of the class in 1990 to the current compounds in clinical development, i.e. around 20 years of research and development efforts. It describes the characteristics of the NNRTIs, their mechanisms of action, HIV resistance to the inhibitors, and the drugs that have been approved for the treatment of HIV infection, that are currently in clinical development. The role of NNRTIs in prevention of HIV transmission is also addressed. The book also covers some basic information about HIV, AIDS and HIV life cycle.

Dr. Amit B. Patel is currently working as an Asst. Professor at HVHP Institute of Postgraduate Studies and Research, KSV University, Kadi, India. His research interest mainly concerned with the development of new Transition-Metal mediated synthesis of variety of new organic and heterocyclic scaffolds, as well as the development of new catalytic systems to facilitate and accelerate chemical reactivity; and pharmaceutical development of biologically active compounds including antibacterial, antifungal, antimycobacterial and anticancer agents. He focuses on the use of alternative solvents in catalysis in an effort to develop more environmentally benign catalytic processes. Current research efforts include development C-C and intramolecular C-N coupling reactions and their implementations in the total synthesis of bioactive molecules.