Antisense Drug Technology : Principles, Strategies, and Applications, Second Edition

Stanley T. Crooke

ISBN 10: 0849387965 / ISBN 13: 9780849387968

Published by Taylor & Francis Inc Jul 2007, 2007

About this Item

Neuware - Divided into five parts, this book offers an introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides.

Seller Inventory # 9780849387968

Bibliographic Details

• Title: Antisense Drug Technology : Principles, Strategies, and Applications, Second Edition
• Publisher: Taylor & Francis Inc Jul 2007
• Publication Date: 2007
• Language: English
• ISBN 10: 0849387965
• ISBN 13: 9780849387968
• Binding: Buch
• Edition: 2nd Edition
• Condition: Neu
• Dimensions: 265W x 188H x 56D millimeters 265 millimeters width by 188 millimeters height by 56 millimeters depth
• Weight: 1766 grams

About this title

Synopsis

Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development.

Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.

Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.

About the Author

Stanley T. Crooke