Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This pathological dysregulation of cell death can be characterized by either too much loss of essential cells in the heart, brain, and other tissues with little regenerative capacity or by too little cell turnover in self-renewing tissues, giving rise to cancer and other maladies. This is a process of fundamental importance for development and normal health, which is altered in many disease conditions. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.

About the Authors

Douglas R. Green is Chair of the Department of Immunology at St Jude Children's Research Hospital, where he also holds the Peter Doherty Endowed Chair. Dr Green came to St Jude in 2005, prior to which he was Head of the Division of Cellular Immunology at the La Jolla Institute of Allergy and Immunology. Dr Green serves as an editor for a number of leading journals and is editor-in-chief of the journal Oncogene.

John C. Reed is Chief Executive Officer of the Sanford-Burnham Medical Research Institute. Dr Reed is also Professor and Donald Bren Executive Chair at Sanford-Burnham, with adjunct professor appointments at several universities. Dr Reed is the recipient of numerous awards and honors and has been awarded more than 76 research grants for his work. He is a named inventor for more than 99 patents and the founder or co-founder of four biotechnology companies. Dr Reed has served as an advisor to numerous biotechnology and pharmaceutical companies and has also served on the boards of directors of several public and private biotechnology companies and life-sciences organizations.

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