Apoptosis in Toxicology

Apoptosis in Toxicology is the first book to focus on the molecular regulation of apoptosis with particular emphasis on toxicant action. Cell survival signalling and its perturbation is addressed at the genetic and biochemical level, including key survival and death genes, survival signalling, commitment to apoptosis and recruitment of the initiator and executioner caspases.
Emphasis is given to the role apoptosis plays in the action of toxicants in the brain, the immune system, the reproductive organs, the kidney and the liver. The ability of drugs to regulate apoptosis either as a target or as an adverse effect is discussed with particular reference to cancer chemotherapy. The many methods that can be employed to quantify apoptosis are compared and their application to different tissues is discussed.
This timely and comprehensive volume has been written by leading authorities and active researchers in their respective fields. It will have broad appeal to toxicologists, physicians and biologists across many disciplines.

Ruth A Roberts leads a research team at Zeneca's Central Toxicology Laboratory with the principle objective of determining the molecular mechanisms of chemical carcinogenesis. This research is focused on how non-genotoxic chemicals induce cell proliferation and regulate constitutive and inducible apoptosis.