Application of Self-assembled Monolayers to Cholesterol Biosensor: Preparation, Characterization and Application of Some Monolayers to Cholesterol Biosensor

Arya, Sunil Kumar, Datta, Monika, D. Malhotra, Bansi

ISBN 10: 3843352828 / ISBN 13: 9783843352826

Published by LAP LAMBERT Academic Publishing, 2010

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Bibliographic Details

• Title: Application of Self-assembled Monolayers to Cholesterol Biosensor: Preparation, Characterization and Application of Some Monolayers to Cholesterol Biosensor
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3843352828
• ISBN 13: 9783843352826
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

A biosensor is an integrated bioanalytical device that employs biological elements, as analyte sensor, coupled to a transducer for signal detection. Biosensor provides sensitive and selective determination of various compounds of analytical relevance. Recently, use of self-assembled monolayer (SAM) is gaining attention as biosensor matrix. SAM provides a simple route to functionalize electrode surfaces for biosensor fabrication. The alarming rise in the rates of heart diseases due to abnormal levels of cholesterol in blood has stimulated public concern about the estimation of cholesterol level in desired sample. The present book highlights the preparation, characterization and application of some SAMs for immobilization of cholesterol oxidase, cholesterol esterase & horseradish peroxidase for development of cholesterol biosensor. The fabricated bioelectrodes were tested for various parameters like pH, temperature, interferents etc. and have been utilized for free and total cholesterol estimation in solution & serum samples. The results indicate that the SAMs are likely to provide useful matrices for the fabrication of commercial cholesterol sensing bioelectrodes.

About the Author

Dr Sunil Kumar Arya has received BSc (Chemistry), MSc (Organic Chemistry) and PhD (Chemistry-Biosensor) from University of Delhi and has published about 28 papers in international journals. At present, he is working as a PostDoc on MEMS based electrochem. biosensor for biomarkers (Cortisol, PSA) detection at University of South Florida, Tampa, USA.