Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer | YAP in Oral Precancer and Oral Squamous Cell Carcinoma

Indumathi Nandhakumar (u. a.)

ISBN 10: 6209363520 / ISBN 13: 9786209363528

Published by LAP LAMBERT Academic Publishing, 2025

About this Item

Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer | YAP in Oral Precancer and Oral Squamous Cell Carcinoma | Indumathi Nandhakumar (u. a.) | Taschenbuch | Englisch | 2025 | LAP LAMBERT Academic Publishing | EAN 9786209363528 | Verantwortliche Person für die EU: SIA OmniScriptum Publishing, Brivibas Gatve 197, 1039 RIGA, LETTLAND, customerservice[at]vdm-vsg[dot]de | Anbieter: preigu.

Seller Inventory # 134442936

Bibliographic Details

• Title: Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer | YAP in Oral Precancer and Oral Squamous Cell Carcinoma
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2025
• Language: English
• ISBN 10: 6209363520
• ISBN 13: 9786209363528
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 6D millimeters 220 millimeters width by 150 millimeters height by 6 millimeters depth
• Weight: 143 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

This study explores the expression of Yes-associated protein (YAP), a key effector of the Hippo pathway, across the spectrum of oral carcinogenesis. Using immunohistochemistry on ethically sourced samples of normal oral mucosa, leukoplakia, and oral squamous cell carcinoma (OSCC), we observed a clear, progressive rise in YAP staining from healthy tissue to dysplasia and finally to OSCC. Dysplastic lesions showed stepwise increases in YAP intensity correlating with severity, while OSCC displayed the highest expression. Both nuclear and cytoplasmic staining were evident, with nuclear positivity (>10%) highlighting YAP’s active transcriptional role in promoting cell growth and malignant transformation. These findings suggest that YAP is a significant biomarker and potential driver of oral cancer progression.