Atherosclerosis: Gene Expression, Cell Interactions, and Oxidation

This book provides a critical review of the oxidative theory of atherosclerosis as well as highlighting new trends in research from basic to clinical, academic to commercial. The contributions of diabetes, vascular dysfunction, blood coagulation, plaque rupture, oxidative stress, lymphocytes, macrophages, growth factors, cytokines, and oxysterols to atherogenesis are all discussed, as are the roles of smooth muscle and endothelial cells. A summary of the current methods of diagnosis and the future prospect of using biochemical markers from plasma is also discussed. There is a critical look at gene therapy and other future therapeutic strategies based on the molecular and cellular causes of atherosclerosis. Each chapter is written by two or more authors from different laboratories to ensure a balanced approach. It will be invaluable to all biochemical researchers with a specialist or passing interest in atherosclerosis research. presents a critical look

Roger Dean is at The Heart Research Institute, Sydney. David Kelly is at The Heart Research Institute, Sydney.