An apico-marginal defect is a combined endodontic periodontal lesion that poses a challenge to the healing outcome and therefore often leads to the decreased prognosis of periapical surgery. Autologous Platelet Aggregates are known to enhance the bone regenrative and healing capacity in such cases. Through this book represents a detailed systematic review of clinical human studies aims to analyze the effect of autologous platelet aggregates on the to clinical and radiographic healing outcome of apico-marginal defects.

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