Automated protein complex modelling

Language: English

Published by Südwestdeutscher Verlag Für Hochschulschriften Jun 2015, 2015

383812376X / 9783838123769

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This item is printed on demand - Print on Demand Titel. Neuware -Protein interaction networks provide an increasingly complex picture of the relationships between macromolecules in the cell. Complementing these interactions with structural data provides critical insights into interaction mechanisms. However, structural information is available only for a tiny fraction of protein interactions and complexes currently known. A method is developed here to predict macromolecular complex structures by systematic combination of pairwise interactions of known structure. An efficient algorithm was designed that exploits heuristics to reduce the large search space. This is complemented with an automated scoring system to filter out the exponentially large number of unrealistic complexes, leaving a ranked set of the most plausible models. On a benchmark set of complexes of known structure, many complexes can be re-created with high accuracy and certain models are much larger and more complete than what is possible with traditional modelling techniques. As the rate of structurally resolved interactions grows, the ability to model larger and more diverse complexes will grow exponentially.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 100 pp. Englisch.…

Seller Inventory # 9783838123769

Title
Automated protein complex modelling
Author
Chad A. Davis
Publisher
Südwestdeutscher Verlag Für Hochschulschriften Jun 2015
Publication year
2015
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
383812376X
ISBN 13
9783838123769
Item weight
167 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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AbeBooks seller since January 23, 2017

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