BACTERIA AND INTRACELLULARITY (HB 2019)

Bacteria and Intracellularity clearly demonstrates that cellular microbiology as a field has reached maturity, extending beyond the strictly cellular level to infections of various organs and tissues. Decades of intense investigation into host-bacterial pathogen interactions have highlighted common concepts in intracellularity but also very diverse mechanisms underlying the various infections produced by bacteria.

This book offers a wide-ranging look at the latest studies, including:

• foodborne pathogens, including how, when, and where bacteria interact with the gut and its microbiota
• infections of the urogenital tract, endothelial barriers, and the nervous system
• major advances in work with Mycobacterium tuberculosis and M. leprae
• subcellular microbiology, including metabolism of infected cells, nuclear biology, and microRNAs
• endosymbionts, in particular the latest work with Wolbachia and its effect on insect transmission of viral pathogens
• research into cell autonomous defense pathways that has led to major insights into immunology and innate immunity
• the latest developments in technology, for the next steps in the study of intracellularity

All facets of cellular physiology, within the entire scope of cells and host tissues, can be targeted by pathogens. This book offers to researchers, students, and laboratorians a valuable overview of the state of current research into the cellular microbiology of host-pathogen interactions.

Pascale Cossart is considered a pioneer in cellular microbiology. Her research has led to new concepts in infection biology as well as in cell biology and fundamental microbiology, including RNA-mediated regulation. Her contributions have been recognized by several international awards and election to several academies, including the National Academy of Sciences and the National Academy of Medicine, and in January 2016 she was named Secrétaire Perpétuel de l'Académie des Sciences, Paris.

Craig R. Roy trained in the laboratory of Stanley Falkow at Stanford University and in the laboratory of Ralph Isberg at Tufts University, and is currently Waldemar Von Zedtwitz Professor of Microbial Pathogenesis and Immunobiology at Yale University. His laboratory uses multidisciplinary approaches to elucidate the mechanisms employed by intracellular pathogens to modulate vesicular transport and the host immune response.

Philippe Sansonetti is professor and head of the Unité de Pathogénie Microbienne Moléculaire at Institut Pasteur in Paris and chair of Microbiology and Infectious Diseases at the Collège de France. Professor Sansonetti is a member of the French Academy of Science, the National Academy of Sciences, and the Royal Society. His investigations concern the pathogenesis of enteric infections, particularly Shigella, including vaccine development and the molecular cross-talk between microbiota and the gut epithelium.