BCL2 Protein Family: Essential Regulators of Cell Death (Advances in Experimental Medicine and Biology)

Claudio Hetz

ISBN 10: 1441967052 / ISBN 13: 9781441967053

Published by Springer, 2010

About this Item

Good+. Hardcover, xvii + 145 pages. An uncirculated university library withdrawal, stamped accordingly. An external stamp on upper and lower page edges, internal library markings on pastedowns & prelims. Pages are clean, bright, with unmarked text and firm binding. Boards show a crease to the upper rear corner, short creases to spine ends, small indentations. Issued without a dust jacket. -- In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL-2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential therapeutic benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism. -- Contents: Homeostatic Functions of BCL-2 Proteins Beyond Apoptosis [Abstract; Introduction; Mitochondrial Energy Metabolism; Autophagy; Protein Quality Control and the Unfolded Protein Response; Physiologic Roles for BCL-2 Family Proteins in Cell Cycle Checkpoints, Differentiation and DNA Damage Response]; Alternative Functions of the BCL-2 Protein Family at the Endoplasmic Reticulum [Abstract; Introduction; BCL-2 Protein Family and the Unfolded Protein Response; Chronic ER Stress and BH3-Only Proteins; BCL-2 Protein Family and the Calcium Rheostat; Autophagy and the BCL-2 Protein Family of Proteins]; BH3-Only Proteins and Their Effects on Cancer [Abstract; Introduction; Categories of BCL-2 Family Proteins and Their Apoptotic Functions; Regulation of Various BH3-Only Proteins and Cell Stress Sensing; BH3-Only Proteins and Cancer Development; BH3-Only Proteins and Chemotherapy Response and Resistance; BH3-Only Mimetic Drugs]; Endoplasmic Reticulum Stress and BCL-2 Family Members [Abstract; Introduction; UPR: The Good and the Evil Side; UPR and BCL-2 Family Members; Autophagy, UPR and BCL-2 Family Members]; Targeting Survival Pathways in Lymphoma [Abstract; Introduction; Pharmacologic Modulation of BCL-2 Proteins and Apoptosis; BCL-2 Proteins and Non-Apoptotic Cell Death]; Interplay Between BCL-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis [Abstract; Introduction; BCL-2 Family; Mitochondrial Shape and Apoptosis]; Noncanonical Functions of BCL-2 Proteins in the Nervous System [Abstract; Introduction; Extending the Traditional View of BCL-2 Family Proteins; Challenging the Traditional BCL-2 Family Model; BCL-2 Family Proteins in the Nervous System; When Anti-Death BCL-2 Proteins Become Pro-Death; When Pro-Death BCL-2 Proteins Protect Neurons; Protection Predicts New Functions with a Seizure; BCL-2 Family Proteins Regulate Synaptic Activity; Mitochondrial Dynamics in Neuronal Function]; Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of Apoptosis [Abstract; Introduction; Regulation of Mitochondrial Fusion and Fission; Mitochondrial Network Dynamics and Cell Homeostasis; Role of Mitochondrial Dynamics in Cell Death; Mechanism of the OMM Permeabilization: A Vital Role for Mitochondrial Fusion and Fission?; Emerging Evidence for the Role of BCL-2 Family Proteins in the Regulation of Mitochondrial Network Dynamics in Healthy Cells].

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Bibliographic Details

• Title: BCL2 Protein Family: Essential Regulators of Cell Death (Advances in Experimental Medicine and Biology)
• Publisher: Springer
• Publication Date: 2010
• Language: English
• ISBN 10: 1441967052
• ISBN 13: 9781441967053
• Binding: Hardcover
• Condition: Good

About this title

Synopsis

In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL‑2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.

About the Author

Claudio Hetz received his BA in Biotechnology Engineering from the University of Chile in 2000. In his PhD work with Claudio Soto at Serono Pharmaceutical Research Institute, Geneva, he showed that Prion pathogenesis involves endoplasmic reticulum stress responses and apoptosis. In 2004 he joined as a postdoctoral fellow Stanley Korsmeyer’s lab at Dana‑Farber Cancer Institute, a pioneer in the apoptosis field. Together they discovered new functions of the BCL‑2 family in organelle physiology. Dr. Hetz followed his projects in Laurie Glimcher’s lab at Harvard. During this period he expanded his studies on neurodegeneration, addressing the connection between apoptosis and the unfolded protein response in vivo. Since 2007 he is an Assistant Professor at the University of Chile and adjunct professor at Harvard. His lab uses animal models to investigate the signaling responses involved in protein misfolding disorders and the role of the BCL‑2 protein family in stress conditions. He was recently awarded with the TWAS‑ROLAC Young Scientist Prize, also as finalist with the Eppendorf and Science Award in Neurobiology, and other important recognitions.