In this volume, a range of experts explore our current understanding of the biology of these important compounds, and identify the prospects for their use in medical and veterinary applications. In so doing, this volume introduces the vast diversity of bacteriocin molecules and mechanisms and brings readers to the cutting edge of a new 21st century approach to antibiotic discovery and design. Topics covered include: the natural history of bacteriocins; killing strategies and applications of microcins; the mode of action of nuclease colicins; the role of the van der Waals zone in the design of a new family of bacteriocins; the use of pyocins in the treatment of infections; the role of streptococccal bacteriocins as oral probiotics; veterinary applications of bacteriocins (nisin) in treating mastitis, and an exploration of the genetics of bacteriocin resistance. This volume is essential reading for everyone involved in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries.

Review

"a comprehensive survey across the current knowledge on these antimicrobial compounds ... a useful addition to microbiology, medical, or ecological reference libraries" from ASM: Small Things Considered

"The book offers an abundance of information" from BioSpektrum

"This excellent book summarises the current state of play as regards our understanding of a wide range of bacteriocin biology ... explores current efforts to develop bacteriocins as alternatives to traditional small molecule antibiotics ... neatly summarises our current understanding of the molecular basis of bacteriocin selectivity and potency at the molecular level, our understanding of bacteriocin ecology and evolution, and how this information is currently being used to develop bacteriocins as useful therapeutics. This book will therefore be of interest to anyone interested in the future development of antibiotics." from Microbiology Today

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