Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design

III David M Wilson

ISBN 10: 9814719722 / ISBN 13: 9789814719728

Published by World Scientific Pub Co Inc, 2017

About this Item

pp. 350.

Seller Inventory # 18373148649

Bibliographic Details

• Title: Base Excision Repair Pathway, The: Molecular Mechanisms And Role In Disease Development And Therapeutic Design
• Publisher: World Scientific Pub Co Inc
• Publication Date: 2017
• Language: English
• ISBN 10: 9814719722
• ISBN 13: 9789814719728
• Binding: Hardcover
• Condition: Used

About this title

Synopsis

This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging process and human disease, such as cancer susceptibility, immunological defects and neurological disorders. The book will also cover the state-of-the-art technologies being developed to assess base excision repair capacity among individuals in the population, in addition to the strategies being employed to target base excision repair as part of therapeutic paradigms to eradicate disease, namely cancer.

This book represents one of the most extensive efforts to date to cover the topic of "base excision repair". It includes chapters by many of the most established investigators in the field, from all over the world.