From Bench to Market: The Evolution of Chemical Synthesis

Cabri, Walter

ISBN 10: 0198503830 / ISBN 13: 9780198503835

Published by Oxford University Press, 2000

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Synopsis:

Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process of industrial chemical synthesis, from the first discovery of a molecule, or 'new chemical entity', to its entry in the marketplace as a drug. They discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies and reaction mechanisms, costs, patent competition, and crystalline forms. The authors use the real chemical history of the development of drugs from several therapeutic areas as detailed case studies, each chosen to illustrate a range of issues and methodologies in industrial chemistry. Several chapters cover the development of the various ß-lactam antibiotics; two chapters describe the discovery and synthesis of the anticancer drugs Idarubicin and Paclitaxal; in another chapter, the synthesis of the anti-viral drug Acyclovir and the 'patent war' that resulted are explored. The technical, practical, and strategic information gathered here make this essential reading for graduate and undergraduate chemists intending to work in the pharmaceutical industry, as well as for industrial chemists themselves. Lecturers teaching courses in medicinal and organic chemistry will also find it useful.

About the Author: Walter Cabri, R+D Director, Research and Development, Antibioticos, Rodano, Italy wcabri@antibioticos.it Romano Di Fabio, Head of CNS Medicinal Chemistry, Medicines and Research Centre, Glaxo- Wellcome, Verona, Italy rdf26781@glaxowellcome.co.uk

Bibliographic Details

Title: From Bench to Market: The Evolution of ...
Publisher: Oxford University Press
Publication Date: 2000
Binding: Soft cover
Condition: Good