Title: Bio Equivalence Study Of Some Antidepressant Drugs: Using Lc-Ms/Ms Technique
Publisher: Lap Lambert Academic Publishing
Publication Date: 2012
Language: English
ISBN 10: 3848447142
ISBN 13: 9783848447145
Binding: Paperback
Condition: Brand New
Weight: 0.28 kilograms

About this title

Synopsis

Drug analysis is important in several phases of pharmaceutical development, such as stability studies, formulation and quality control. Several techniques have been employed in the development of analytical methods for drug quantification in both biological fluids and dosage forms. The latter is the simplest kind of sample due to its high analyte content and few matrix effects, so a large number of techniques and methods are suitable for drug quantification in dosage forms. The bioanalytical methods for the determination of some antidepressant drugs are quantified in biological matrix. In this book, the development and validation of UPLC-MS/MS methods for the quantification of some antidepressant drugs (paroxetine, amitriptyline and its metabolite) in human plasma are described. All the developed methods were found selective, sensitive and rapid. They have simple extraction procedure and a short run time. They were also found suitable for clinical pharmacokinetics studies in healthy human volunteers following oral administrations.

About the Author

Dr Sanjay Shah is an eminent researcher & Principal of Pilvai Sc College,INDIA.He is the author of several books and research papers published in reputed journals. He guided 9 PhD students.Dr Mitesh Bhatt has obtained his PhD degree in analytical chemistry. He has worked in various research projects. He published several papers in reputed journals

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