The main objective of this study is to formulate and evaluate of Bioadhesive pulsatile drug delivery system of an antilipidemic drug. In order to achieve a improved therapeutic efficacy. The present research works describe the combination of Bio adhesive pulsatile principle are very suitable for site and time specific. Gastroretentive drug delivery is an approach to prolong gastric residence time, thereby targeting site specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effects. Several gastro retentive drug delivery approaches being designed and developed ,including :high density (sinking)systems that is retained in the bottom of the stomach, low density (floating)systems that causes buoyancy in gastric fluid ,mucoadhesive systems that causes bio adhesion to stomach mucosa ,unfoldable ,extendible, or swellable systems. The bio adhesive pulsatile tablet was prepared satisfactorily with no weight variation and hardness within official limit.in drug release study lag time up to 7hrs .thus bioadhesive pulsatile drug delivery system is best option for an antilipdemic patients.

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