Bioanalytical Investigation:Management of Hypertension Using Doxazosin | Doxazosin using internal standard doxazosin D8 by LC/MS/MS system used in the management of hypertension

Publisher

LAP LAMBERT Academic Publishing

Publication Date

2017

Language

English

ISBN 10

3330074833

ISBN 13

9783330074835

Binding

Taschenbuch

Condition

Neu

Dimensions

Weight

268 grams

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Synopsis

Development in the bioanalytical technology & the application of pharmacokinetic (PK) principles has created a synergistic partnership that plays a vital, influential role in the discovery and development of new medicines. In the bioanalytical investigation a fast, sensitive, accurate and reproducible high performance liquid chromatography-mass spectrometry method has been developed & validated for the quantitative estimation of DOXAZOSIN in human plasma using DOXAZOSIN D8 used as internal standard by solid phase extraction (SPE) technique.Doxazosin, is an oral drug used for treating high blood pressure and symptoms of benign prostatic hyperplasia, it belongs to the class of alpha -1 adrenergic blockers. It prevents Norepinephrine that is released by nerves from binding to alpha -1 receptors on smooth muscles surrounding blood vessels and in prostate and bladder by blocking the effect of norepinephrine, Doxazosin relaxes the smooth muscles, relaxation of smooth muscle surrounding blood vessels causes them to enlarge (dilate) and thereby reduces blood pressure.

About the Author

Anil Kumar Sahdev* (Assistant Professor), Monika Bhandari ( M.Pharma), Khushboo Gupta (M.Pharma)Innovative College of Pharmacy, Greater Noida (Uttar Pradesh).India

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