Biochemical Alterations Induced by Fluoride & Deltamethrin in Rats: Biochemical & Oxidative Alterations Induced by Toxic Interaction of Deltamethrin & Fluoride in Rats

Dubey, Nitin, Raina, Rajinder, Verma, Pawan Kumar

ISBN 10: 3659234095 / ISBN 13: 9783659234095

Published by LAP LAMBERT Academic Publishing, 2013

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Bibliographic Details

• Title: Biochemical Alterations Induced by Fluoride & Deltamethrin in Rats: Biochemical & Oxidative Alterations Induced by Toxic Interaction of Deltamethrin & Fluoride in Rats
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2013
• Language: English
• ISBN 10: 3659234095
• ISBN 13: 9783659234095
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

The study was aimed to investigate the effect of deltamethrin and fluoride alone & their combination on different blood biochemical & antioxidant parameters in wistar rats. 24 healthy rats of either sex weighing 150-200G were divided in 4 groups with 6 rats in each group. Group I were untreated and served as control. Group II received deltamethrin orally @ 1.28 mg/kg, BW (1/100 of LD50) daily for 4 weeks. Group III was administered sodium fluoride @ 44.5 mg/ L in drinking water (providing 20 ppm of fluoride in water) daily for 28 days. Group IV received both deltamethrin & fluoride at the same doses and manner as in groups II & III. Deltamethrin alone elevated the levels of SGOT & SGPT whereas fluoride increased AST and proteins. Both toxicants alone decreased the levels of erythrocyte AChE activity. However, co-administration of deltamethrin and fluoride elevated plasma enzymes more prominently. Among the stress parameters, significant increase was observed in LPO & GST activity but significant decrease in activities of GSH-Px, SOD & CAT. The observations indicate that both deltamethrin & fluoride alone & in combination induce marked alterations in biochemical & stress parameters.

About the Author

Nitin Dubey presently working as Veterinary Assistant Surgeon, Department of Animal Husbandry, Jammu & Kashmir, INDIA. He completed his Post Graduation from Division of Pharmacology & Toxicology, F V Sc & A H, R S Pura, Jammu in 2010. He published three research papers in international journals and presented 4 abstract in different conferences.