Biochemistry of Drug Metabolizing Enzymes (Paperback)

Biochemistry of Drug Metabolizing Enzymes: Trends and Challenges is a complete and well-integrated reference on their mechanisms of action, their role in diseases, agents responsible for their deactivation, and their malfunction. Chapters explain the biochemistry of DMEs, including biochemical activation, functions, computational approaches, different contaminants on the action and function of DMEs, and describe the importance of DMEs in the drug development process. Conditions covered include metabolic diseases, cardiovascular diseases, neurological diseases, physiological diseases, xenobiotics and inflammatory responses, and their contribution in the malfunctioning of drug metabolizing enzymes.

This book is the perfect resource for pharmacology and biochemistry researchers to understand the principles of DMEs. Researchers in the corporate environment will also benefit from the comprehensive list of diseases associated with malfunction of DMEs.

• Includes extensive classification of DMEs, their mechanism of action and computational analysis
• Covers the biotransformation of drug by DMEs and the possible impact of environmental contaminants
• Discusses the activity of DMEs in different clinical conditions such as cardiovascular disease, metabolic disorders, inflammation and neurotoxicity
• Includes modern and novel bioanalytical techniques to predict the effect of DMEs

Dr. Akash is currently working as an Associate Professor at the Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan. He got his PhD degree in Pharmaceutical Analysis from Zhejiang University, China. Currently, he is focusing on investigating the effect of endocrine disrupting
chemicals on various molecular and metabolic pathways that are involved in metabolic disorders and their treatment strategies. His research work is cutting-edge and worthy of extension in developing countries, like Pakistan, where it can be most beneficial and cost-effective, especially for diabetic patients. Based on his significant scientific contributions in
the field of Pharmaceutical Sciences, he has been awarded “Research Productivity Awards” from the Pakistan Council for Science and Technology, the PAS Gold Medal from the Pakistan Academy of Sciences, and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan.

Dr. Kanwal Rehman is working as an Associate Professor at the Department of Pharmacy in The Women University, Multan, Pakistan. Dr. Rehman received her PhD in Pharmacology from Zhejiang University, China. She nurtures
a keen interest in the pathogenesis of metabolic disorders and new therapeutic modalities for its treatment. Currently, she
is focusing on the investigation of the role of pharmacogenomics based upon gene polymorphism on various molecular and
metabolic pathways that are involved in mitogenic disorders and treatment strategies, like natural biogenic compounds against different risk factors of metabolic disorders, including pancreatitis, cardiometabolic disorders, and hormonal imbalance. Dr. Rehman has also been awarded the Research Productivity Award by the Pakistan Council for Science and Technology, Pakistan; the PAS Gold Medal from the Pakistan Academy of Sciences; and the A.R. Shakoori Gold Medal from the Zoological Society of Pakistan.