Biofunctionalized Magnetic Nanoparticles for Cancer Theragnostics: Design,Synthesis and Biofunctionalization of Magnetic Nanoparticles for Targeted Cancer Therapy and Diagnostic Imaging

Das, Manasmita, Basak, Amit, Pramanik, Panchanan

ISBN 10: 3848406314 / ISBN 13: 9783848406319

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Biofunctionalized Magnetic Nanoparticles for Cancer Theragnostics: Design,Synthesis and Biofunctionalization of Magnetic Nanoparticles for Targeted Cancer Therapy and Diagnostic Imaging
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3848406314
• ISBN 13: 9783848406319
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

Superparamagnetic iron-oxide nanoparticles with tailored surface chemistry may be regarded as one of the most popular multifunctional materials for biomedical applications. Their unique capabilities to enhance the proton relaxation of specific tissues, coupled with outstanding magnetic manipulability make them highly promising probes/ vectors for magnetic resonance imaging (MRI) contrast enhancement, magnetic fluid hyperthermia (MFH) for selective destruction of cancer cells and magnetically modulated drug or gene delivery. The present study contributes some new tool-boxes for the facile, water-based synthesis of biocompatible coating-stabilized multifunctional iron-oxide nanoparticles (MNPs), simultaneously integrated with fluorophores, targeting agents and/ or chemotherapeutic drugs. Herein, we describe some novel strategies to design and synthesize theragnostic MNPs that can simultaneously trace, target and kill cancer cells while allowing a real time monitoring of drug delivery through combined MR and fluorescence imaging.

About the Author

Dr. Manasmita Das pursued her PhD in Chemistry from IIT Kharagpur under the joint supervision of Prof. Amit Basak and Prof. Panchanan Pramanik. Currently, she is working as a postdoctoral fellow in NIPER Mohali under Dr. Sanyog Jain. Her research focuses on the development of "smart", multifunctional nanocarriers for theragnostic applications.