Bioinformatic Approaches to Structure and Function of Protein: Structural and Functional Analysis of Rhodopsin

Kanwal, Shagufta, NIshat, Sumaira, Khan, Muhammad Irfan

ISBN 10: 3846584363 / ISBN 13: 9783846584361

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Bioinformatic Approaches to Structure and Function of Protein: Structural and Functional Analysis of Rhodopsin
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3846584363
• ISBN 13: 9783846584361
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

This book provides a compact knowledge about practical applications of bioinformatic approaches to understand the structure and function of a protein- Rhodesian which is found in visual pigment of eye and responsible for controlling night vision. Its structure has been predicted by comparative homology modelling and model evaluation through various tools. The electron density maps of retinal isomers and structure of rhodopsin intermediates were analyzed by structure superimposition. On the basis of structural analysis of thirteen mutations for Autosomal Dominant Retinitis Pigmentosa, one of the missense mutation has been targeted to propose a drug to cure night blindness. The molecular docking technique has also been used to predict ligand interactions with rhodopsin. It is hoped that this will provide new insights into structural and functional exploration of proteins which will be helpful in understanding various vital phenomena like protein activation and inhibition, drug interactions and protein signaling.

About the Author

Shagufta Kanwal is presently lecturer of Bioinformatics and Biotechnology at International Islamic University Islamabad, Pakistan. She has research publications on major domains of bioinformatics in accompany of her coleague Sumaira Nishat,presently bioinformatics lecturer, under the infallible motivation and guidance of Prof. Muhammad Irfan Khan.