Bioinformatics with Python Cookbook: Use modern Python libraries and applications to solve real-world computational biology problems, 3rd Edition

Discover modern, next-generation sequencing libraries from the powerful Python ecosystem to perform cutting-edge research and analyze large amounts of biological data

Key Features

• Perform complex bioinformatics analysis using the most essential Python libraries and applications
• Implement next-generation sequencing, metagenomics, automating analysis, population genetics, and much more
• Explore various statistical and machine learning techniques for bioinformatics data analysis

Book Description

Bioinformatics is an active research field that uses a range of simple-to-advanced computations to extract valuable information from biological data, and this book will show you how to manage these tasks using Python.

This updated third edition of the Bioinformatics with Python Cookbook begins with a quick overview of the various tools and libraries in the Python ecosystem that will help you convert, analyze, and visualize biological datasets. Next, you'll cover key techniques for next-generation sequencing, single-cell analysis, genomics, metagenomics, population genetics, phylogenetics, and proteomics with the help of real-world examples. You'll learn how to work with important pipeline systems, such as Galaxy servers and Snakemake, and understand the various modules in Python for functional and asynchronous programming. This book will also help you explore topics such as SNP discovery using statistical approaches under high-performance computing frameworks, including Dask and Spark. In addition to this, you'll explore the application of machine learning algorithms in bioinformatics.

By the end of this bioinformatics Python book, you'll be equipped with the knowledge you need to implement the latest programming techniques and frameworks, empowering you to deal with bioinformatics data on every scale.

What you will learn

• Become well-versed with data processing libraries such as NumPy, pandas, arrow, and zarr in the context of bioinformatic analysis
• Interact with genomic databases
• Solve real-world problems in the fields of population genetics, phylogenetics, and proteomics
• Build bioinformatics pipelines using a Galaxy server and Snakemake
• Work with functools and itertools for functional programming
• Perform parallel processing with Dask on biological data
• Explore principal component analysis (PCA) techniques with scikit-learn

Who this book is for

This book is for bioinformatics analysts, data scientists, computational biologists, researchers, and Python developers who want to address intermediate-to-advanced biological and bioinformatics problems. Working knowledge of the Python programming language is expected. Basic knowledge of biology will also be helpful.

Table of Contents

1. Python and the Surrounding Software Ecology
2. Using Data Processing Libraries: numpy, pandas, arrow, and zarr
3. Next Generation Sequencing
4. Advanced NGS Data Processing
5. Working with Genomes
6. Population Genetics
7. Phylogenetics
8. Using the Protein Data Bank
9. Bioinformatics Pipelines
10. Machine Learning for Bioinformatics
11. Parallel Processing with Dask
12. Functional and Asynchronous Programming

Tiago Antao is a bioinformatician currently working in the field of genomics. A former computer scientist, Tiago moved into computational biology with an MSc in Bioinformatics from the Faculty of Sciences at the University of Porto (Portugal) and a PhD on the spread of drug-resistant malaria from the Liverpool School of Tropical Medicine (UK). Postdoctoral, Tiago has worked with human datasets at the University of Cambridge (UK) and with mosquito whole genome sequencing data at the University of Oxford (UK), before helping to set up the bioinformatics infrastructure at the University of Montana. He currently works as a data engineer in the biotechnology field in Boston, MA. He is one of the co-authors of Biopython, a major bioinformatics package written in Python.