The Biology of Aging: Observations and Principles
Language: English
Published by Oxford University Press, 2006
- Hardcover
- Used
Condition: Used - Fair
US$ 13.84
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Unbekannte Unterschrift / Widmung; Anmerkungen / beschriftet / Stempel; Leichte Kratzer / Abnutzungen / Druckstellen; Leichte Anmerkungen / Beschriftungen. Robert Arking's Biology of Aging, 3rd edition, serves as an essential introductory text for advanced undergraduate and graduate students, providing a comprehensive review of the biology of aging. This edition highlights significant recent advancements in understanding both the ultimate and proximate mechanisms of aging. Key updates include clarified distinctions between longevity determination and senescent processes, along with a new conceptual framework to help readers organize and interpret the latest findings. Enhanced insights into aging cells reveal how they transition from healthy to senescent states, accommodating high levels of variability. The text discusses senescent mechanisms, emphasizing that aging results from a nonprogrammatic loss of function due to diminished regulatory signals, which can be modified in laboratory settings. It also addresses recent research on intergenerational resource transfers, challenging traditional evolutionary narratives regarding social organisms. As aging mechanisms are shown to be plastic, there is an increasing demand for anti-aging interventions in humans. The book presents biological and ethical arguments surrounding this issue, framing it thoughtfully. Fifteen focused chapters summarize extensive data on aging, with the final chapters integrating this material into a cohesive understanding of biological changes throughout the lifespan. Arking posits that pharmaceutical extension.…
Seller Inventory # 95cc8738-4a62-42a9-b2bb-c74a4a08855d
- Title
- The Biology of Aging: Observations and Principles
- Author
- Robert Arking
- Publisher
- Oxford University Press
- Publication year
- 2006
- Condition
- Fair
- Binding
- Hardcover
- Language
- English
- ISBN 10
- 0195167392
- ISBN 13
- 9780195167399
- Edition
- 3rd Edition
· Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. · A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. · Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. · Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. · Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. · Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner.
The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.
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