Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health: Annual Report Fy 1981 (Classic Reprint)

Explore a snapshot of NIH engineering research from 1980–1981, where modeling, materials science, and advanced instrumentation drive advances in therapy and diagnostics.

This collection summarizes projects from the Biomedical Engineering and Instrumentation Branch, detailing how mathematical models, biomaterials, and novel instruments are used to understand and improve medical treatments. It highlights how in vitro and in vivo studies, computer-assisted tools, and clinical applications come together to address problems in drug delivery, implants, imaging, and tissue analysis.

• Pharmacokinetics modeling for anticancer drugs and CNS barriers, including intraperitoneal administration and lung involvement.
• Implant device development, biomaterial interactions, and surface engineering for cardiovascular and other implants.
• Picosecond spectroscopy and optical engineering, focusing on fast molecular processes and detector linearity in pulsed measurements.
• Microcirculation analysis and coherent light scattering, using laser Doppler flow and Doppler spectroscopy for non-invasive tissue blood flow monitoring.
• Advanced instrumentation efforts in electron microscopy, mass spectrometry calibration, and energy-dispersive X-ray imaging to study biological samples.