Bioorganic Chemistry of Biological Signal Transduction (Topics in Current Chemistry, Volume 211)

Herbert Waldmann et al

ISBN 10: 3540677461 / ISBN 13: 9783540677468

Published by Springer, Germany, 2001

About this Item

3540677461. Hardcover, from closed pharmaceutical company library. English text. 239 pages, Author index for Volumes 201-211, illustrated with charts, tables and diagrams. Sections: Protein Tyrosine Kinase Inhibitors as Therapeutic Agents; Peptidomimetic SH2 Domain Antagonists for Targeting Signal Transduction; Biophysical Characterization of the Ras Protein; Ras-Farnesyltransferase-inhibitors as Promising Anti-Tumor Drugs; Phosphatidyylcholine-Preferring Phospholipase C from B. cereus. Function, Structure and Mechanism; Photoaffinity Labeling in Biological Signal Transduction. Contents unread, as new, clean, tight and bright.

Seller Inventory # 030339

Bibliographic Details

• Title: Bioorganic Chemistry of Biological Signal Transduction (Topics in Current Chemistry, Volume 211)
• Publisher: Springer, Germany
• Publication Date: 2001
• Language: English
• ISBN 10: 3540677461
• ISBN 13: 9783540677468
• Binding: Hardcover
• Illustrator: William Smuts (Maps)
• Condition: Fine
• Dust Jacket Condition: Poor
• Book Type: Book
• Seller catalogs:
  • Chemistry

About this title

Synopsis

The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced, belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate, for instance, the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors. These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology, medical research and chemistry working in academic research institutions or in indus