Biosynthesis - Polyketides and Vitamins, (Topics in Current Chemistry, 195)

Leeper, F.J.; Vederas, J.C.

ISBN 10: 3540634185 / ISBN 13: 9783540634188

Published by Springer, Germany, 1997

About this Item

3540634185. Hardcover, from closed pharmaceutical company library. English text. 215 pages, Author index for Volumes 151-195, illustrated with charts, tables and diagrams. Sections: Application of Isotopic Methods to Secondary Metabolic Pathways; Biosynthesis of Aliphatic Polyketides; Cofactor Biosynthesis: A mechanistic Perspective; Biosynthesis of Vitamin B12. Contents appears unread, clean, tight and bright.

Seller Inventory # 022909

Bibliographic Details

• Title: Biosynthesis - Polyketides and Vitamins, (Topics in Current Chemistry, 195)
• Publisher: Springer, Germany
• Publication Date: 1997
• Language: English
• ISBN 10: 3540634185
• ISBN 13: 9783540634188
• Binding: Hardcover
• Condition: Near Fine
• Dust Jacket Condition: No Jacket
• Book Type: Book
• Seller catalogs:
  • Chemistry

About this title

Synopsis

The present volume is the first of two planned to provide state-of-the-art expert reviews of central topics in modern natural products chemistry and secondary metabolism. Many scientists not directly involved in these areas still view the field of natural products as focused primarily on the isolation,structure elucidation, and cataloging of new compounds (i. e. “grind and find”),or on their chemical synthesis. However,two revolutions in experimental techniques since the early 1950’s have completely transformed the understanding of chemical and biological relationships between highly diverse natural products. The first was the use isotopes to label precursors and follow the fate of key atoms during biochemical transformations to a final product. Advances in methodology that began in the mid-1970’s,especially using NMR to detect stable isotopes,dramatically expanded the level of mechanistic detail available to study in vivo conversions of secondary metabolites. The second revolution started in the late 1980’s as researchers developed methods to identify,purify and genetically manipulate individual enzymes - sponsible for the intricate steps leading to complex natural products. This has expanded the field from building an encyclopaedia of natural materials to being able to initiate control of biochemical pathways to secondary metabolites. Recent advances suggest it may soon be possible to rationally manipulate biochemical pathways in vivo to rapidly produce almost any target molecule,including n- natural variants,in substantial quantity.